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KMID : 1134819990280051113
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 5 p.1113 ~ p.1123
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Effects of Glucosamine Hydrochloride, Taurine and Their Combined Administration on Anti - inflammatory and Analgesic Action in Rats
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Kim Ok-Kyoung
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Abstract
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The purpose of this study was to see the effect of anti-inflammatory and analgesic action of the glucosamine hydrochloride(GA-HCl) or taurine. Male Sprague-Dawley rats(100~250g) and ICR mice(20~30g) were used. Experimental groups were divided into seven groups, one control group given as saline and six groups given as oral administration of GA-HCl or taurine; GA-HCl 250㎎/㎏, b.w group, taurine 250㎎/㎏, b.w group, GA-HCl 250㎎/㎏, b.w+taurine 250㎎/㎏, b.w group, GA-HCl 500㎎/㎏, b.w group, taurine 500㎎/㎏, b.w group, GA-HCl 500㎎/㎏, b.w+taurine 500㎎/㎏, b.w group. Carrageenan induced edema test were shown to be significantly inhibited in the GA-HCl 250㎎/㎏ group and taurine 250㎎/㎏ group compared to the control group, but the GA-HCl 500㎎/㎏+taurine 500㎎/㎏ group were significantly inhibited than the control group. Capillary permeability test were shown to be significantly inhibited in the taurine 500㎎/㎏ group, but the GA-HCl 500㎎/㎏+taurine 500㎎/㎏ group were significantly inhibited than the control group. Leucocyte emigration test were shown to be significantly inhibited in the GA-HCl 250㎎/㎏+taurine 250㎎/㎏ group and GA-HCl 500㎎/㎏+taurine 500㎎/㎏ group compared to the control group. Acetic acid, Phenyl-p-benzoquinone writhing syndrome were shown to be significantly inhibited in the GA-HCl 500㎎/㎏+taurine 500㎎/㎏ group compared to the control group. Inhibitory action against COX-1 and COX-2 were not significantly inhibited in the experimental group. These results suggest that the combined administration of the GA-HCl and taurine have potential action in anti-inflammatory and analgesic action.
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KEYWORD
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glucosamine hydrochloride, taurine, anti-inflammatory and analgesic action, COX
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